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amount of leptin working its way through the body is directly related to the total amount of fat in the body. Human and animal research indicates that it may play aninfluential role in fat loss and obesity-related cardiovascular disease. Recent examinations suggest that the cardiovascular actions of leptin may help explain the link between excess fat mass and cardiovascular diseases. It is produced by a specific gene found in fat cells called the obese or (ob) gene. Small amounts of leptin are also secreted by cells in the epithelium, stomach and placenta. The amount of leptin found in people increases as their body fat increases. One theory is that as you get fatter you also get less attuned to the affects of leptin. This is why fat loss may be more than just cutting calories.
Let’s see how it acts on the body to promote fat loss in the following ways;
? counteracts the effects of neuropeptide Y which is a feeding stimulant secreted by cells in the gut wall and in the hypothalmus
? counteracts the affects of anandamid which is another feeding stimulant that binds to the same receptors as THC
? promotes the effects of alpha-MSH which is an anti-inflammatory agent and another appetite-suppressing hormone which results in you eating less and greater fat loss
? it also stimulates secretion of reproductive hormones such as gonadotrophin-releasing hormone and thus leutenizing and follicle stimulating hormone from the anterior pituitary.
? it raises the temperature of the subject so energy expenditure is increased which burns more calories and promotes more fat loss
? acts directly on the cells of the liver and skeletal muscles where it stimulates the oxidation of fatty acids in the mitochondria which reduces the storage of fat in those tissues
What Can We Do To Increase Leptin Sensitivity?
1.) Increase protein intake
2.) Exercise
3.) Increase Zinc
4.) Increase Vitamin E
5.) Try a low glycemic index diet
6.) Try using a carb loading diet (Warning not for the inexperienced or faint of heart)
If you are looking to promote fat loss, leptin should definitely be on your radar.
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